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KMID : 1103720190800020318
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Journal of the Korean Society of Radiology
2019 Volume.80 No. 2 p.318 ~ p.332
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Contrast-Enhanced Ultrasound Parameters in Breast Cancer: Correlations with Prognostic Factors
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Lee Myoung-Eun
Kim Sung-Hun
Kang Bong-Joo
Lee Youn-Joo
Kim Yun-Ju
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Abstract
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Purpose: To correlate the value of contrast-enhanced ultrasound (CEUS) with prognostic factors of breast cancer.
Materials and Methods: 24 breast cancer patients were evaluated with CEUS. As a quantitative analysis, the peak enhancement (PE), wash-in and wash-out area under curve (WiWoAUC), wash-in rate (WiR) and wash-out rate, rise time, fall time, mean transit time, time to peak, and wash-in perfusion index (WiPI) were measured. As a qualitative analysis, the enhancement patterns were evaluated. Pathologic prognostic factors, including histologic grade, hormonal receptors and Ki-67 proliferative index were assessed by immunohistochemistry. Correlation of quantitative and qualitative parameters of CEUS with prognostic factors was assessed.
Results: We found that the quantitative CEUS values (PE, WiWoAUC, and WiPI) of estrogen receptor (ER) positive breast cancer were higher than those of ER negative counterpart (all p < 0.05). Lower quantitative CEUS values (PE, WiWoAUC, WiR, and WiPI) were found in triple-negative cancer (TNC) than those of non-TNC (all p < 0.05). No CEUS parameter showed significant difference in distinguishing histologic grade (all p > 0.05).
Conclusion: The CEUS parameters were helpful in predicting prognostic factors, such as ER positivity or triple negativity. However, they could not predict the histologic grade.
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KEYWORD
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Breast Neoplasms, Ultrasonography, Prognosis, Receptors, Progesterone, Receptors, Estrogen, Immunohistochemistry
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